About Vyvanse
(lisdexamfetamine dimesylate)

Vyvanse helps control ADHD. You and your child do the rest.

Vyvanse was shown to provide ADHD symptom control throughout the day and into the evening in children aged 6 to 12 with ADHD.

In one study in children aged 6 to 12:

  • When taken at 7 am, Vyvanse provided ADHD symptom control at 8:30 am.*
  • Vyvanse demonstrated ADHD symptom control throughout the day and into the evening — even at 8 pm.*

* Based on Swanson, Kotkin, Agler, M. Flynn, and Pelham Deportment Scores (SKAMP-DS)

In another clinical study in children aged 6 to 12:

  • Parents reported symptom improvement in the morning, afternoon, and into the early evening.

Based on Conners’ Parent Rating Scale

Who should not take Vyvanse?

Your child should not take Vyvanse if he or she:

  • Is taking or has taken within the past 14 days an anti-depressant called a monoamine oxidase inhibitor (MAOI)
  • Is sensitive to, allergic to, or had a reaction to other stimulant medications.

Learn about Vyvanse side effects

In 2013, Vyvanse was approved by the FDA for maintenance treatment in children aged 6 to 17

A study in children with ADHD who took Vyvanse for at least 6 months and whose symptoms were well controlled evaluated the benefit of extended treatment with Vyvanse.

During the first 4 weeks of the study, children were started on a dose of Vyvanse; the dose was adjusted as needed for the next 20 weeks. After 2 weeks of observation without any changes to the dose, children were randomly placed in 1 of 2 groups: half of the children continued to take Vyvanse while the other half were switched to placebo (sugar pill).

At the end of the study:

  • 84.2% of children maintained ADHD symptom control with Vyvanse, compared to 32.5% with a sugar pill.

Treatment failure was defined as ≥50% increase (worsening) in the ADHD Rating Scale IV (ADHD-RS-IV) Total Score and ≥2-point increase in the Clinical Global Impression-Severity (CGI-S) score compared to scores at entry into the double-blind phase.

Learn about Getting Started on Vyvanse

Vyvanse (lisdexamfetamine dimesylate) may not be right for everyone

Your child should take Vyvanse exactly as the doctor tells him or her to take it.
Before starting treatment for ADHD with Vyvanse, tell your child's doctor about all health conditions (or a family history of), including:

  • Heart problems, heart defects, or high blood pressure
  • Mental problems, including psychosis, mania, bipolar illness, or depression
  • Circulation problems in fingers and toes
  • Any previous or current drug or alcohol abuse

Tell the doctor if your child is pregnant, breast-feeding or planning to become pregnant, or breast-feed, and about all of the medication your child takes.

Common questions about Vyvanse

Can Vyvanse capsules be opened and mixed in certain liquids or soft foods?
What is the recommended Vyvanse dosage?
How soon does Vyvanse start working and how long does it last?
Can Vyvanse be stopped on weekends or for “drug holidays”?
How should Vyvanse treatment be discontinued?
Why is the doctor changing the dosage of my child’s ADHD medicine?
What are the common side effects of Vyvanse?
Is there a Vyvanse (lisdexamfetamine dimesylate) patient assistance program?

Can Vyvanse capsules be opened and mixed in certain liquids or soft foods?

If your child has trouble swallowing capsules, open the Vyvanse capsule and pour all the powder into yogurt, water, or orange juice.

  • Use all of the Vyvanse powder from the capsule so your child gets all of the medicine.
  • Using a spoon, break apart any powder that is stuck together. Stir the Vyvanse powder and yogurt, water, or orange juice until they are completely mixed together.
  • Your child should eat all the yogurt or drink all the water or orange juice right away after it has been mixed with Vyvanse. Do not store the yogurt, water, or orange juice after it has been mixed with Vyvanse. It is normal to see a filmy coating on the inside of the glass or container after your child eats or drinks all the Vyvanse.

What is the recommended Vyvanse dosage?

The doctor will work with your child to find the dosage that works best — increasing it if your child’s symptoms aren’t well controlled or decreasing it if your child experiences side effects. It’s important that your child takes Vyvanse exactly as the doctor tells him or her to take it. And it’s also important to keep talking with the doctor while your child is taking Vyvanse.

How soon does Vyvanse start working and how long does it last?

In a clinical trial of children aged 6-12 with ADHD, Vyvanse was shown to start working 1.5 hours after taking the medication.* Vyvanse was shown to be effective for ADHD symptoms 13 hours after the morning dose.* The onset and duration of Vyvanse in adolescents have not been studied. However, in an adult clinical trial, the average time for the medication to start working was 2 hours after taking it, and Vyvanse was shown to be effective for ADHD symptoms 14 hours after the morning dose.§ Please talk to your child’s doctor for more information.

* Based on Swanson, Kotkin, Agler, M.Flynn, and Pelham Deportment scores (SKAMP-DS)

§ Based on the Permanent Product Measure of Performance (PERMP)

Can Vyvanse be stopped on weekends or for “drug holidays”?

Your child’s doctor or health care provider can determine the best course of treatment for your child. Make sure you talk with the doctor before stopping or changing the dose of your child’s medication.

How should Vyvanse treatment be discontinued?

Only the doctor can determine the proper course of treatment for your child, including when to start or whether to stop Vyvanse. Talk to your child’s doctor before stopping Vyvanse.

Why is the doctor changing the dosage of my child’s ADHD medicine?

The doctor may adjust the dosage of your child’s medication. It may require time to determine which dose of medication is right for your child. Your child should take Vyvanse exactly as the doctor tells him or her to take it.

What are the common side effects of Vyvanse?

Vyvanse may cause serious side effects including slowing of growth (height and weight) in children. The most common side effects of Vyvanse include: anxiety, decreased appetite, diarrhea, dizziness, dry mouth, irritability, loss of appetite, nausea, trouble sleeping, upper stomach pain, vomiting, and weight loss. These are not all the possible side effects of Vyvanse. For more information, ask your doctor or pharmacist.

Is there a Vyvanse (lisdexamfetamine dimesylate) patient assistance program?

Shire Cares Patient Assistance and Support is a program designed for patients with financial need. This program may be able to cover all or a portion of the cost of the Vyvanse medication that the doctor has prescribed for your child. To learn more, visit www.shirecares.com or call 1-888-CARES-55 (1-888-227-3755).

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What should I know about using ADHD medications?

Get a parent’s guide to proper stimulant use