Side Effects for Vyvanse (lisdexamfetamine dimesylate)

Every medication has side effects. That’s why it’s so important to understand the potential risks before starting treatment with Vyvanse.

Review this page to learn about Vyvanse side effects. Keep in mind that this is not a complete list of risks. For additional safety information for Vyvanse, please see the Vyvanse Prescribing Information and Medication Guide and discuss them with your child’s doctor. Then work with your child’s doctor to address any side effects that occur.

What is the most important information I should know about Vyvanse?

Vyvanse is a federally controlled substance (CII) because it can be abused or lead to dependence. Keep in a safe place to prevent misuse and abuse. Selling or sharing Vyvanse may harm others and is illegal.

Tell the doctor if your child has (or you have a family history of having) ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Vyvanse is a stimulant medicine. The following have been reported with use of stimulant medicines.

  1. Heart-related problems including:
    • sudden death in people who have heart problems or heart defects
    • sudden death, stroke, and heart attack in adults
    • increased blood pressure and heart rate

Tell the doctor if your child has any heart problems, heart defects, high blood pressure, or a family history of these problems. Your doctor should check you or your child’s blood pressure and heart rate regularly during treatment with Vyvanse.

Call your child's doctor right away if your child has any signs of heart problems such as chest pain, shortness of breath, or fainting while taking Vyvanse.

  1. Mental (psychiatric) problems including:
    • new or worse behavior and thought problems
    • new or worse bipolar illness

    In Children and Teenagers

    • new psychotic symptoms such as:
      • seeing things or hearing voices that are not real
      • believing things that are not true
      • being suspicious
    • new manic symptoms

Tell the doctor about any drug abuse, alcohol abuse or mental problems that your child has had, or about a family history of suicide, bipolar illness, or depression.

Call your child's doctor right away if your child has any new or worsening mental symptoms or problems while taking Vyvanse.

  1. Circulation problems in fingers and toes [Peripheral vasculopathy, including Raynaud's phenomenon]:
    • Fingers or toes may feel numb, cool, painful, sensitive to temperature and/or change color from pale, to blue, to red.

Call your doctor right away if you have or your child has any of these signs or symptoms or develops unexplained wounds on fingers or toes while taking Vyvanse.

Tell the doctor if you or your child is pregnant, breast-feeding, or plans to become pregnant or breast-feed.

Who should not take Vyvanse?

Your child should not take Vyvanse if he or she:

  • Is taking or has taken within the past 14 days an anti-depressant medicine called a monoamine oxidase inhibitor (MAOI)
  • Is sensitive to, allergic to, or had a reaction to other stimulant medicines

What are some common side effects of Vyvanse?

The most common side effects reported in studies of Vyvanse were

  • Anxiety
  • Decreased appetite
  • Diarrhea
  • Dizziness
  • Dry mouth
  • Irritability
  • Loss of appetite
  • Nausea
  • Trouble sleeping
  • Upper stomach pain
  • Vomiting
  • Weight loss

These are not all the possible side effects for Vyvanse. Ask your child’s doctor or pharmacist for more information and talk to your child’s doctor about any side effects your child may be experiencing.

For more information on Vyvanse side effects, please see Vyvanse Prescribing Information and Medication Guide and discuss with your child’s doctor or pharmacist.

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